Lipid solubility cell penetration
This was some of the first evidence that cells were surrounded by a lipid The correlation between permeability and solubility in lipidly is appropriately named.
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INTRODUCTION
PERMEABILITY OF MOLECULES
Description:Melatonin is recognized as a circulating hormone signifying night for both diurnal and nocturnal vertebrates Reiter, The secretory mechanism determines the modes of physiological regulation. Surprisingly, some small polar molecules are capable of permeating the lipid bilayer without the aid of a membrane transport protein. Or are they so permeant that they always leave the cell by simple diffusion as fast as they are synthesized, like endocannabinoids and nitric oxide? The diffusion coefficient D is a measure of the rate of entry into the cytoplasm depending on the molecular weight or size of a molecule.
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